“Clinicians have successfully trialled a drug for autism that eases many of the symptoms of the condition,” caught my attention today. In my rudimentary reserach, here is what I uncovered:
The drug: Arbaclofen.
The M.O.: Attempts to re-balance the brain chemistry of those with autism.
The Preliminary Results: Reduced tantrums, calmer mood, and more sociable.
Other Useful Information: The International Society for Autism Research (INSAR) published a study in May 2010 that concluded, “Advances in the neurobiological understanding of FXS and autism are now leading to the development of targeted pharmacotherapeutics for these conditions. Abundant challenges remain in the translation of neurobiology to clinical therapy, but trials of some rationally-justified agents are already underway. Interim results indicate that arbaclofen shows good safety and tolerability in subjects with FX aged 6 to 40 years.”
Lifescience Online reports: “AP (arbaclofen placarbil) is a Transported Prodrug of the R isomer of baclofen. Baclofen is a generic drug that is currently approved to treat spasticity and has been shown in investigator-led studies to be effective in the treatment of GERD. AP is designed to overcome the deficiencies of baclofen by targeting high-capacity nutrient transporter mechanisms expressed throughout the length of the entire GI tract, including the colon.”
What have you found? What do you think?